Published in Gene Therapy Weekly, May 4th, 2006
"Hepatic steatosis is a core feature of the metabolic syndrome and type 2 diabetes and leads to hepatic insulin resistance. Malonyl-CoA, generated by Acc1 and Acc2, is a key regulator of both mitochondrial fatty acid oxidation and fat synthesis," wrote D.B. Savage and colleagues, Yale University.
They continued, "We used a diet-induced rat model of nonalcoholic fatty liver disease (NAFLD) and hepatic insulin resistance to explore the impact of suppressing...
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