Herpes Simplex Virus
Herpes simplex virus Ala substitution enhances or abolishes cell fusion activity and viral entry
Published in Gene Therapy Weekly, May 4th, 2006
"HSV glycoprotein B (gB) is one of the four viral glycoproteins required for viral entry and cell fusion and is highly conserved among herpesviruses," wrote N. Ruel and colleagues, Northwestern University.
"Mutants of HSV type 2 gB were generated by substituting conserved residues in the cytoplasmic tail with Ala or by deleting 41 amino acids from the C-terminus. Some of the mutations abolished cell fusion activity and also prevented transport of gB to the cell surface, identifying residues in the gB...
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Source: Gene Therapy Weekly (2006-05-04)
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