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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . May 11th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Antisense Technology - Antisense oligodeoxynucleotides can be delivered from cationically modified polymer films

Antisense Technology - Morpholino antisense oligonucleotides inhibit Oct4 expression

Cancer Gene Therapy - Breast cancer cell invasiveness is affected by matrix metalloproteinase

Gene Therapy - Calcitonin gene-related peptide receptor is activated by gene transfer

Gene Transfer - Gene transfer and enzyme replacement eliminates abnormal fibroblast sialylglycoproteins

Alveolar Cancer - Bronchoalveolar cell carcinoma is reduced by gene-modified dendritic cells

Angiology - Proper vascular development depends on calponin production

Angiology - TASK-2 channels function in rat pulmonary arteries

Antigens - Ezetimib influences the expression of raft-associated antigens in human monocytes

Antivirals - Antiviral effect of liposome-mediated IL-28 and IL-29 demonstrated on WISH cells

Apoptosis - New findings from the United States in the area of apoptosis described

Apoptosis - Research from Ireland, the South Korea and Japan add new data to apoptosis body of knowledge

Apoptosis - Researchers' work from Japan and the United Kingdom adds to apoptosis body of knowledge

Apoptosis - Thymocyte apoptosis is minimized by PI3K delta and PI3K gamma

Biotechnology - Cytovance Biologics launches cell banking and storage practice

Breast Cancer - Breast cancer angiogenesis and invasion decline when uPA-uPAR signals are incapacitated

Breast Cancer - Breast cancer correlates with the expression of the FRA16D cancer gene

Breast Cancer - Breast cancer growth may be related to enhanced SMYD3 expression

Breast Cancer - Findings from the United Kingdom, Japan and United States describe new data in breast cancer research

Business Update - Celera Genomics announces sale of therapeutic programs to Pharmacyclics

Business Update - Dalton Pharma Services announces completion of GMP oligonucleotide manufacturing suite

Business Update - Expanded access program for Rexin-GTM provides genetic medicine to cancer patients

Cancer Gene Therapy - Adenovirus-mediated gene therapy in osteosarcoma cell lines can be sensitized

Cancer Gene Therapy - Breast cancer gene therapy effectiveness is increased by adenoviral vectors

Cancer Gene Therapy - Chemokine-expressing adenoviral vector suppresses tumors

Cancer Gene Therapy - Delivery of monocyte chemoattractant protein-1 gene enhances colon antitumor effects

Cancer Gene Therapy - Gene delivery to ovarian carcinoma nodes can be mediated

Cancer Gene Therapy - Gene therapy of human glioblastomas indicated by antiangiogenic activity of BAI1

Cancer Gene Therapy - Gene-based vaccination produces immune responses against PSMA

Cancer Gene Therapy - Growth arrest of head and neck cancer cells correlates with increased p16 and p53 expression

Cancer Gene Therapy - Interleukin gene therapy enhances ifosfamide activity against osteosarcoma lung metastases

Cancer Gene Therapy - Targeted cancer gene therapy for small-cell lung cancer utilizes a novel promoter

Cancer Gene Therapy - Transfection sensitizes tumor cells to etoposide-induced apoptosis

Cancer Research - Researchers from the People's Republic of China, United States and Germany describe findings in cancer studies

Cancer Research - Studies from Spain and the United States add new findings to cancer body of knowledge

Cancer Research - Studies from the United States and Czech Republic advance knowledge in cancer research

Cancer Therapy - Akt-activated cancer is suppressed by inhibited protein kinase activation

Cancer Therapy - Thiazoloquinazolines found to be selective Aurora A and B kinase inhibitors

Cancer Treatment - New findings from the United States and China in the area of cancer treatment described

Cancer Treatment - New research from Germany, the United States and Switzerland in the area of cancer treatment detailed

Cancer Treatment - Researchers from Finland, the United States and Germany report recent findings in cancer treatment

Cancer Vaccine - Cancer vaccine therapy is improved using genetically modified dendritic cells

Cardiology - Researchers from Japan and the United States provide details of new studies and findings in the area of cardiology

Cell Recruitment - CXCL16-mediated cell recruitment is dependent upon the MAPK pathway

Clinical Trials - Corautus announces termination of patient enrollment in GENASIS severe angina clinical trial

Collaborations - Correlagen Diagnostics and Protedyne Corporation partner to form Correlagen GeneXchange

Collaborations - GNI and Beijing Continent Pharmaceutical agree to form strategic alliance

Colon Cancer - New data from Scotland, the United States and Netherlands lluminates research in colon cancer

Colorectal Cancer - Colorectal cancer tumor marker is a homologue of the Drosophila headcase protein

Crohn Disease - Crohn disease-associated polymorphisms display extreme heterogeneity

DNA - New data from Netherlands, France and South Korea lluminates research in DNA

DNA - Recent findings in DNA described by researchers from Japan, Belgium and Ireland

DNA - Researchers from the People's Republic of China, United States and Netherlands report recent findings in DNA

DNA Research - An shRNA barcode screen provides insight into cancer cell vulnerability

DNA Research - Endonuclease G participates in nucleosomal DNA fragmentation

Dermatology - Epidermolytic hyperkeratosis is caused by a human keratin 10 knockout

Developmental Biology - Growth differentiation factor is required for ovary primordial follicle development

Diabetes - New data from Japan, the North Ireland and Germany lluminates research in diabetes

Diabetes - New findings from Sweden, Israel and the United States in the area of diabetes detailed

Drug Delivery - Data from Wales, the United States and Japan advance knowledge in drug delivery research

Drug Delivery - Research from Japan, the South Korea and Singapore add new data to drug delivery body of knowledge

Drug Development - Tumor cells and angiogenesis yield to a new transcriptional inhibitor

Drug Resistance -  Haemophilus influenzae cefotaxime resistance involves altered binding proteins

Endocrinology - Calcitonin receptor-stimulating peptide-1 affects energy homeostasis

Endometrial Carcinoma - Endometrial carcinoma linked to CEACAM1 expression

Esophageal Cancer - Polo-like kinase and survivin are esophageal tumor-specific promoters

Fabry Disease - Amicus Therapeutics announces European regulatory status on Amigal for Fabry disease

Facilities - CombiMatrix Molecular Diagnostics establishes facility in Toronto

Finance - CombiMatrix and Texas A&M University receive grant, focus is DNA hybridization on microarrays

Gastric Cancer - Gastric cancer metastasis reversed by selected peptide20

Gene Delivery - Targeted gene delivery is facilitated by genospheres

Gene Therapy - Researchers from Italy, Japan and the United States detail new studies and findings in the area of gene therapy

Genetics - Recent findings from the United Kingdom, United States and South Korea illuminate research in genetics

Genetics - Reports from Austria, Italy and the United States add new data to genetics research

Genetics - Studies from the United States and Japan add new findings to genetics body of knowledge

Genetics & Genomics - Enzyme crystal structure reveals unexpected genome repair functions

Genetics & Genomics - Gene profiling study identifies a unique G3139 molecular signature

Genetics & Genomics - Gentris Corporation introduces human genomic DNA reference controls for CYP2D6 gene

Genetics & Genomics - Human cementum-derived protein characterized

Genetics & Genomics - New method utilized for analyzing histocompatibility complex in human genome

Glioblastoma - Glioblastoma cell autophagy is regulated by elongation factor-2 kinase

Gliomas - Gliomas are eradicated by von Hippel-Lindau tumor suppressor protein overexpression

Hepatitis C Virus - Recent studies from the United States add new data to hepatitis C virus research

Hepatocellular Carcinoma - Hepatocellular carcinoma involves acyl-CoA:cholesterol acyltransferase 2 gene expression

Herpes Simplex Virus - HSV-TK-modified donor T cells limited after hematopoietic cell transplantation

Herpes Simplex Virus - Oncolytic recombinant herpes simplex virus treats orthotopic liver tumors

Herpes Simplex Virus - Synergistic herpes simplex virus cytotoxicity achieved using double suicide gene therapy

Hodgkin Lymphoma - Classical Hodgkin lymphoma gene silencing involves epigenetic processes

Hodgkin Lymphoma - Hodgkin lymphoma involves high expression of activating transcription factor 3

Human Papillomavirus - Human papillomavirus vaccination utilizes recombinant adeno-associated virus

Imaging - Researchers from the United States and Belgium detail new studies and findings in the area of imaging

Influenza Vaccine - GEN ID Lab Services Inc. to clone entire H5N1 influenza virus genome to develop new vaccines

Kaposi Sarcoma - Kaposi sarcoma-associated herpesvirus lytic switch protein DNA binding interactions explored

Kinases - Isolated kinase regulatory domains undergo isoform-specific conformational changes

Leukemia - Reports from Japan and the United States advance knowledge in leukemia research

Leukemia - Researchers attempt to unlock the mystery of acute lymphoblastic leukemia

Lung Cancer - COX-2 inhibitors suppress lung cancer cell growth

Lung Cancer - Researchers' data from Japan, the United States and the People's Republic of China advance lung cancer research

Lymphoma - Diffuse large B cell lymphoma linked to inactivation of PRDM1/BLIMP1 gene

Measles - Research from the United States add new data to measles body of knowledge

Melanoma - Recent findings from Germany and the United States illuminate research in melanoma

Multiple Sclerosis - Reports from the United States, Germany and Netherlands describe recent advances in multiple sclerosis research

Myelodysplasia Prognostic Markers - Immature hematopoietic progenitor cells CD34+/CD38(Dim) increased in myelodysplasia

Myeloma - Four additional cancer centers join Multiple Myeloma Research Consortium

Neuroscience - Gemin8 functions in small nuclear ribonucleoprotein assembly

Neuroscience - Hippocampal up-regulation plays a key role on spatial memory

Neuroscience - Neurons active during paradoxical sleep localized

Ophthalmology - Retina nyctalopin localized

Osteoarthritis - Osteoarthritic cartilage gene expression analyzed in intact and damaged regions

Ovarian Cancer - Mucinous epithelial ovarian cancer displays a distinct molecular profile

Ovarian Cancer - Ovarian cancer invasion suppressed by overexpressed HOX genes

Pancreatic Adenocarcinoma - Pancreatic adenocarcinoma progression linked to Src activation

Patents - Emisphere receives additional patent for technology to enhance pulmonary delivery of proteins

Personnel - Conquer Fragile X chairman and founder Harris Hollin appointed to President's Committee

Personnel - EXACT Sciences announces changes to management team

Personnel - Exagen Diagnostics names Thomas O'Connor vice president, sales

Personnel - Genomic Health announces appointment of Dr. Woodrow Myers to board of directors

Personnel - Genomic Profiling Systems names new CEO to drive commercialization of Growth Direct system

Pertussis -  Bordetella bronchiseptica-secreted effector functions in necrotic cell death

Prostate Cancer - CD44+ prostate cancer cells are enriched in tumorigenic and metastatic progenitor cells

Proteomics - S-nitrosylated proteins identified after deoxycholate exposure of colon epithelial cells

RNA - Reports from Taiwan, the United States and Israel add new data to RNA research

Rheumatoid Arthritis - Rheumatoid arthritis is targeted by antibodies to Epstein-Barr virus nuclear antigen

Squamous Cell Carcinoma - Squamous cell carcinoma kinase A protein expression is down-regulated

Stem Cell Research - Immortalized endothelial progenitor cells offer a way to study new vessel growth

Thrombospondin - Thrombospondin structural homology repeat functions in connective tissue growth

Thyroid Cancer - Thyroid cancer cell p53 family member function is inhibited by HMGA1

Transplant Medicine - XDx announced data validate benefits of molecular testing in transplant patients

Vectors - New findings in vectors described from Germany, the United States and the People's Republic of China

Vectors - New research from Slovakia and the United States in the area of vectors detailed

Virology - Interferon signaling is inhibited by rabies virus phosphoprotein P

Virology - Research from the United States, Brazil and France in virology provides new insights

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