Antisense Technology
Morpholino antisense oligonucleotides inhibit Oct4 expression
Published in Gene Therapy Weekly, May 11th, 2006
"MO can induce gene silencing by binding to a target mRNA and inhibiting its translation, and this technique has been especially successful in studies of embryonic development in various vertebrates. But in mice MO-induced downregulation of target genes has not been widely reported," wrote I. Tsuji and colleagues, Kinki University of Medicine.
They continued, "In this study, we examined whether MO delivery using ethoxylated polyethylenimine (EPEI) delivery reagent is useful for silencing gene expression in the mouse preimplantation embryo, by...
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Source: Gene Therapy Weekly (2006-05-11)
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