Gene Therapy

Calcitonin gene-related peptide receptor is activated by gene transfer

Published in Gene Therapy Weekly, May 11th, 2006

According to a study from the United States, calcitonin gene-related peptide (CGRP) receptor is activated by receptor activity-modifying protein-1 gene transfer to vascular smooth muscle cells.

"The neuropeptide CGRP is a potent vasodilator that plays a protective role in the cardiovascular system. The receptor for CGRP is an unusual complex of the G protein-coupled calcitonin-like receptor and an obligate receptor activity modifying protein-1 (RAMP1)," wrote Z.M. Zhang and colleagues, University of Iowa. "In this report we provide the first evidence that RAMP1 is rate limiting in vascular smooth muscle cells."

"Although cultured rat aorta smooth...

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Source: Gene Therapy Weekly (2006-05-11)

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