Crohn Disease
Crohn disease-associated polymorphisms display extreme heterogeneity
Published in Gene Therapy Weekly, May 11th, 2006
"The first gene associated with CD has been identified as CARD15 (16q12). Three variants, R702W, G908R and 1007fsinsC are strongly and independently associated with the disease.
"A second gene, conveying a smaller risk for inflammatory bowel disease (IBD), has been identified as DLG5 (10q23). We assess the frequency of the CARD15 SNPs and of the R30Q mutation in DLG5 and their contribution to the development of CD in a cohort of unrelated IBD patients (151 CD, 325 ulcerative colitis (UC)) and healthy controls (236) from South-east...
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Source: Gene Therapy Weekly (2006-05-11)
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