Geriatrics
Somatic gene transfer of CREB attenuates memory impairment in aging rats
Published in Gene Therapy Weekly, May 25th, 2006
"CREB is important for the formation and facilitation of long-term memory in diverse models. However, to our knowledge, involvement of CREB in age-associated memory impairment has not been reported," wrote A. Mouravlev and colleagues, Ohio State University.
They continued, "Here, we use a recombinant adeno-associated virus vector to obtain stable transgenic expression of CREB as well as the inducible cAMP early repressor (ICER) in the hippocampus of adult rats."
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Source: Gene Therapy Weekly (2006-05-25)
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