Cancer Therapy
Aplidin oxidizes and inactivates a low molecular weight protein Tyr phosphatase
Published in Gene Therapy Weekly, May 25th, 2006
"The marine plitidepsin Aplidin derived from the Mediterranean tunicate Aplidium albicans is a strong apoptotic inducer with promising antitumor activity. However, little is known about the mechanism of action of the molecule.
"In this article, we report that Aplidin is cytotoxic for NIH3T3 cells and that its action is exerted through the production of reactive oxygen species (ROS)," wrote M.L. Taddei and colleagues, University of Florence.
"Rotenone, but not other selective inhibitors of ROS production, blocks...
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Source: Gene Therapy Weekly (2006-05-25)
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