Cardiology
Angiogenic suicide gene cell therapy regulates the effect of angiogenesis in infarcted hearts
Published in Gene Therapy Weekly, May 25th, 2006
"Although angiogenic gene therapy has been reported to be effective in restoring ischemic heart function, there are several obstacles to its clinical application, such as unreliable efficiency of transfection and uncontrollable expression," wrote S. Miyagawa and colleagues, Osaka University.
They continued, "We developed human HGF (hHGF)-producing cells that regulated hHGF production using the thymidine kinase gene of herpes simplex virus (TK) and the ganciclovir (GCV) system."
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Source: Gene Therapy Weekly (2006-05-25)
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