Adenoviral Vector
Replication properties of human adenovirus in different animal species described
Published in Gene Therapy Weekly, May 25th, 2006
According to a study from Germany, "Oncolytic adenoviruses have emerged as a promising approach for the treatment of tumors resistant to other treatment modalities. However, preclinical safety studies are hampered by the lack of a permissive nonhuman host. Screening of a panel of primary cell cultures from seven different animal species revealed that porcine cells support productive replication of human adenovirus type 5 (Ad5) nearly as efficiently as human A549 cells, while release of...
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Source: Gene Therapy Weekly (2006-05-25)
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