Apoptosis

Induced apoptosis protection of INS-1 cells conferred by mitochondria targeting

Published in Gene Therapy Weekly, May 25th, 2006

A recent study from the United States has reported that induced apoptosis protection of INS-1 cells is conferred by mitochondria targeting.

"Chronic exposure to elevated levels of free fatty acids (FFAs) impairs pancreatic beta-cell function and contributes to the decline of insulin secretion in type 2 diabetes. Previously, we reported that FFAs caused increased nitric oxide (NO) production, which damaged mitochondrial DNA (mtDNA) and ultimately led to apoptosis in INS-1 cells," wrote L.I. Rachek and colleagues, University of Southern Alabama.

They continued, "To firmly establish the link between FFA-generated mtDNA damage and apoptosis, we stably...

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Source: Gene Therapy Weekly (2006-05-25)

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