Gene Therapy Weekly

Adverse Drug Reaction - Prolonged beta-interferon stimulation causes DNA damage signaling and p53-dependent senescence

Developmental Biology - Lung morphogenesis is influenced by Iroquois genes during development

Developmental Biology - Osteoblastic differentiation markers altered by connexin43 modulation

Hepatitis B Virus - HBV gene expression and replication are inhibited by stable RNA interference

Neuroscience - Developing aneural myotubes display myogenin-dependent nAChR clustering

Allergy & Immunology - Deacetylation regulates innate antiviral response and beta interferon gene expression

Allergy & Immunology - Immune responses involve interferon-associated signaling pathway cross-talk

Allergy & Immunology - Neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia

Angiology - Bone morphogenetic protein signaling controls PASMC K-V channel expression

Apoptosis - Apoptosis kinase contributes to induced apoptosis through positive feedback

Awards - Expression Genetics, Inc. EGEN-001 cancer therapeutic included in "Top 100" list

Bladder Physiology - Plasma membrane Ca²⁺-ATPase functions in bladder contraction-relaxation processes

Breast Cancer - Breast cancer cell macrophage-induced invasion requires Wnt 5a signaling

Business & Finance - Compugen reports decreased sales revenue in first quarter

Business Update - Crucell presents update on strategy and operations at analyst briefing

Business Update - DrugMEt pharmacogenetics product achieves CE Mark for IVD use

Cancer Gene Therapy - Aptamers target tumors

Cancer Gene Therapy - Cancer therapies should be designed by targeting function of individual genes

Cancer Gene Therapy - CD99 acts as an oncosuppressor in osteosarcoma

Cancer Gene Therapy - Gene disruption occurs in ES cells lacking the mismatch repair protein MSH3

Cancer Gene Therapy - Multiple oncolytic herpes simplex virus vectors generated

Cancer Gene Therapy - T cell lymphoma proliferation and apoptosis is affected by STAT5

Cancer Gene Therapy - UGT1A1 expression in colon cancer repressed by DNA methylation

Cancer Therapy - Melanoma cell activation and stable hypomethylation is caused by transient DNMT1

Cell Biology - The PTEN/PI3-kinase/Akt pathway regulates microvascular structure stability

Cell Physiology - Lung fluid absorption was inhibited by RNA interference

Cell Physiology - Stretch increases alveolar epithelial permeability to uncharged micromolecules

Cell Regulation - Nuclear factor of activated T cells regulates tumor necrosis factor production

Colitis - In T cell-mediated colitis, regulatory T cells suppress effector memory T cells

Collaborations - Circadian Technologies Limited announces major agreement with Ludwig Institute and Licentia

Collaborations - Cobra Biomanufacturing to work with International AIDS Vaccine Initiative and GSK Biologicals

Collaborations - CombiMatrix and Prisma expand relationship in China, Taiwan, and other countries

Collaborations - CombiMatrix to collaborate on U.S. early detection system for avian influenza

DNA Vaccine - Transfection of cells was effective with multishell calcium phosphate-DNA nanoparticles

Developmental Biology - Innexin gap junction protein heteromerization regulates epithelial tissue organization

Developmental Biology - Wnt and LIF act synergistically to maintain pluripotency of embryonic stem cells

Diabetes Research - Inhibition of aldose reductase may prevent glucose-induced stimulation of SMC growth

Drug Development - Adeno-associated viral vectors can aid treatment of neurological disorders

Drug Development - Herpesvirus has been designed to enter cells solely via IL-13 alpha 2 receptor

Drug Development - Influenza protein augments avian influenza hemagglutinin pseudotyping of lentiviral vectors

Drug Development - Modified montmorillonite functions as vector for gene delivery

Finance - Diversa reports restructuring charges of $11 million in first quarter

Finance - Sangamo BioSciences reports Q1 2006 consolidated net loss of $2.7 million

Gastroenterology - Gastric epithelial cell proliferation involves K(V)1.1 and Na(V)1.5

Genetics & Genomics - A Prospero-related homeodomain protein is a novel co-regulator

Genetics & Genomics - NXP-2 association with SUMO-2 depends on Lys required for transcriptional repression

Glioblastomas - Glioblastomas display angiogenesis reduction upon telomerase inhibition

Haemophilus Influenzae -  Haemophilus influenzae porin-related proinflammatory activity clarified

Hematology - Cell-mediated lysis of autologous platelets occurs in chronic idiopathic thrombocytopenic purpura

Hepatitis B Virus - HBV-associated nephropathy clarified by kidney gene expression profile

Huntington Disease - Huntington disease neuropathology ameliorated in a model mouse

Huntington Disease - Transgenic Huntington disease rat displays normal excitotoxicity sensitivity

Hyperalgesia - Hyperalgesia is engaged by concerted action of inflammatory mediators

Hypercholesterolemia - Isis 301012 reduces cholesterol and triglycerides in patients with high cholesterol

Imaging - Scavidin-receptor imaged in human umbilical vein endothelial cells