Adverse Drug Reaction
Prolonged beta-interferon stimulation causes DNA damage signaling and p53-dependent senescence
Published in Gene Therapy Weekly, June 1st, 2006
"Interferons are cytokines with potent antiviral and antiproliferative activities. We report that although a transient exposure to beta-interferon induces a reversible cell cycle arrest, a sustained treatment triggers a p53-dependent senescence program," wrote O. Moiseeva and colleagues, University of Montreal.
"Beta-interferon switched on p53 in two steps. First, it induced the acetylation of p53 at Lys 320 and its dephosphorylation at Ser-392 but not p53 activity. Later on, it triggered a DNA signaling pathway, the...
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Source: Gene Therapy Weekly (2006-06-01)
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