Cancer Gene Therapy
Host Stat1 deficiency enhances interleukin-12-mediated tumor regression
Published in Gene Therapy Weekly, June 8th, 2006
"Stat1 is considered a key transcription factor that inhibits tumorigenesis, and Stat1 activation in the host is required for interleukin-12 (IL-12)-mediated generation of CTL activity. Using syngeneic Stat1-/- C3H mice bearing SCCVII tumors in this study, we discovered opposite results," wrote M.N. Torrero and colleagues, Louisiana State University.
"Stat1 deficiency in the host significantly enhances IL-12-mediated...
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Source: Gene Therapy Weekly (2006-06-08)
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