Gene Therapy
Plasmid-based gene transfer for investigating muscle structure and function has been optimized
Published in Gene Therapy Weekly, June 8th, 2006
According to recent research published in the journal Molecular Therapy, "Intramuscular injection of naked plasmid DNA is a less cytotoxic alternative to viral vectors for delivering genetic material to skeletal muscle in vivo. However, the low efficiency of plasmid-based gene transfer limits its potential therapeutic efficacy and/or its use for many experimental applications."
"Current strategies to enhance transfection efficiency (i.e., electroporation) can cause significant muscle damage, confounding physiological assessments such...
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Source: Gene Therapy Weekly (2006-06-08)
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