Renal Carcinoma
Clear cell renal carcinoma MET phosphorylation induced by gene inactivation
Published in Gene Therapy Weekly, June 8th, 2006
"It is well known that inactivation of VHL gene predisposes for human CCRC. However, details about critical roles of VHL inactivation during tumorigenesis are still unknown," wrote N. Nakaigawa and colleagues, Yokohama City University.
"MET protein is a Tyr kinase receptor for hepatocyte growth factor/scatter factor (HGF/SF), which regulates cell growth, cell morphology, and cell motility. We showed that MET protein overexpressed in CCRC cells was phosphorylated without HGF/SF. This...
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Source: Gene Therapy Weekly (2006-06-08)
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