Glioma
Putative mediator of growth arrest and death identified in malignant glioma cells
Published in Gene Therapy Weekly, June 8th, 2006
"Chimeric tumor suppressor-1 (CTS-1) is based on the sequence of p53 and was designed as a therapeutic tool resisting various mechanisms of p53 inactivation. We previously reported that an adenovirus expressing CTS-1 (Ad-CTS-1) has superior cell death-inducing activity in glioma cells compared with wild-type p53.
"Here, we used cDNA microarrays to detect changes in gene expression preferentially induced by Ad-CTS-1," wrote U. Naumann and colleagues, University of Tubingen.
"The putative Ser...
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Source: Gene Therapy Weekly (2006-06-08)
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