Renal Cell Carcinoma
Fibrinolytic factors in metastatic renal cell carcinoma cells down-regulated by Connexin 32
Published in Gene Therapy Weekly, June 8th, 2006
"Fibrinolytic factors have an important role in tumor progression through the degradation of extracellular matrix. The increased levels of urokinase-type plasminogen activator (uPA), uPA-receptor (uPAR) and type-1 PA inhibitor (PAI-1) are reported in human RCC. Cx gene, a member of gap junction, is known to act as a tumor suppressor gene. We have reported that Cx32 improves malignant phenotypes of metastatic RCC cells via the inhibition of Src-dependent signaling," researchers in Japan reported.
"In this study, we examined the effect of...
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Source: Gene Therapy Weekly (2006-06-08)
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