Published in Gene Therapy Weekly, June 8th, 2006
Study 1: A study from Japan has reported that monocyte chemoattractant protein-1 (MCP-1) gene delivery enhances antitumor effects of herpes simplex virus Thy kinase/ganciclovir system in a model of colon cancer.
"Suicide gene therapy using the herpes simplex virus Thy kinase/ganciclovir (HSV-tk/GCV) system is a well-characterized tool for cancer gene therapy; however, it does not yet exhibit sufficient efficacy to cure patients of malignancies. We have reported that adenovirally delivered monocyte chemoattractant protein (MCP)-1 augmented the...
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