Lymphoma
Researchers' data from the United States advance lymphoma research
Published in Gene Therapy Weekly, June 15th, 2006
Study 1: B cell lymphoma could be linked to inactivation of the PR domain containing 1 with zinc finger domain (PRDM1)/B lymphocyte-induced maturation protein 1 (BLIMP1) gene.
According to a study from the United States, "PRDM1/BLIMP1 is a transcriptional repressor expressed in a subset of germinal center (GC) B cells and in all plasma cells, and required for terminal B cell differentiation. The BLIMP1 locus lies on chromosome 6q21-q22.1, a region frequently deleted in B cell lymphomas, suggesting that it may harbor a tumor suppressor gene."
"We report here that the...
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Source: Gene Therapy Weekly (2006-06-15)
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