Developmental Biology
Integrin maturation promoted by beta 1,4-galactosyltransferase down-regulation
Published in Gene Therapy Weekly, June 15th, 2006
"In previous study, we have shown that GaIT V functions as a positive growth regulator in glioma. Here, we reported that down-regulation of the expression of GaIT V in SHG44 cells by transfection with antisense cDNA specifically up-regulated the expression of cell surface integrin beta I without the change of its mRNA, and with integrin beta 1 125 kDa mature form increased and 105 kDa precursor form decreased," wrote X.N. Chen and colleagues, Fudan University.
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Source: Gene Therapy Weekly (2006-06-15)
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