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Developmental Biology

Neurotrophic factor is required for developmental plasticity

Published in Gene Therapy Weekly, June 15th, 2006

According to research from Israel, brain-derived neurotrophic factor (BDNF) is critically involved in thermal-experience-dependent developmental plasticity.

"All species exhibit critical period for sensory development, yet very little is known about the molecules involved in the changes in the network wiring that underlies this process. Here the role of BDNF in the critical period of thermal control establishment in chicks was investigated," wrote A. Katz and colleagues, Agriculture Research Organization.

"Neuroanatomically, the body temperature is balanced by the preoptic anterior hypothalamus (PO/AH) and controlled by thermosensitive neurons....

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