Cell Differentiation

Astrocyte heterogeneity is revealed by expression of a GFAP-LacZ transgene

Published in Gene Therapy Weekly, June 15th, 2006

A study from the United States has reported that astrocyte heterogeneity is revealed by expression of a glial fibrillary acidic protein (GFAP)-LacZ transgene.

"GFAP is an intermediate filament protein present primarily in astrocytes. The gene is first expressed as astrocytes mature, and in the adult is strongly upregulated in response to CNS damage," wrote Y. Lee and colleagues, University of Alabama.

"Thus," they continued, "in addition to its astrocyte specificity, transcriptional regulation of the GFAP gene is of interest as a reporter of CNS signaling during development and injury."

"Several laboratories have shown that...

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Source: Gene Therapy Weekly (2006-06-15)

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