Genetics & Genomics

PRAF2 genomic organization and expression characterized

Published in Gene Therapy Weekly, June 15th, 2006

Recent research from the United States has reported on the genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2).

"PRAF2 is a new 19 kDa protein with four putative transmembrane (TM) domains. PRAF2 (formerly designated JM4) belongs to a new protein family, which plays a role in the regulation of intracellular protein transport," wrote C.S. Fo and colleagues, University Hawaii at Manoa.

"Recently, PRAF2 was found to interact with the chemokine receptor CCR5 [Schweneker, M., Bachmann, A.S., Moelling, K., 2005. JM4 is a four-transmembrane protein binding to the CCR5 receptor. FEBS Lett....

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Source: Gene Therapy Weekly (2006-06-15)

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