Immunotherapy
Immunogenic anti-CD3 antibody-interleukin-2 fusion protein developed
Published in Gene Therapy Weekly, June 15th, 2006
"T cells can be activated in vitro by monoclonal antibodies to CD3 (anti-CD3) to become non-MHC restricted killer cells (CD3-AK). Anti-CD3 activation upregulates the expression of the interleukin (IL)-2 receptors on T cells whose expansion is facilitated by IL-2," wrote K.D. Lee and colleagues, Chang Gung Memorial Hospital.
"The therapeutic effect of in vivo administration of anti-CD3 and IL-2 has been investigated in many types of human cancers. To circumvent the...
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Source: Gene Therapy Weekly (2006-06-15)
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