Gene Therapy Weekly

DNA Research - Aberrant ocular albinism gene splicing can be corrected

Immunotherapy - Immunotherapeutic potential of adenoviral-mediated gene transfer revealed

RNA Interference - Mammalian gene expression is artificially controlled by modulating RNA interference

RNA Interference - Short hairpin RNAs delivered into mouse embryonic stem cells

Respiratory Medicine - Airway inflammation is facilitated by local blockade of T-bet expression

Allergy & Immunology - T cell receptor codon modification enhances functional expression

Ameloblastoma - Ameloblastoma compared with dentigerous cyst via oligonucleotide microarrays

Amyloidosis - Hereditary systemic amyloidosis amyloidogenic transthyretin can be selectively suppressed

Angiology - Angiogenic growth proceeds without marrow cell incorporation after VEGF stimulation

Apoptosis - Apoptosis is suppressed by a binding peptide aptamer

Apoptosis - Apoptotic chromatin fragmentation is inhibited by loss of acinus

Blood Vessel Regeneration - CD11(low) cells are a good source of cells for blood vessel regeneration

Breast Cancer Therapy - Study demonstrates Genomic Health's Oncotype DX helps predict breast cancer survival

Brucellosis Vaccine - DNA vaccine encoding Brucella abortus genes is protective in mice

Business & Finance - DNAPrint Genomics updates first quarter business activity

Business Update - Cepheid launches CE Mark-certified Smart VZV in vitro diagnostic test for SmartCycler Platform

Business Update - Gen-Probe, DiagnoCure provide updates on PCA3 prostate cancer collaboration

Cancer Gene Therapy - Chimeric promoter highly responsive to hypoxia and metals is identified

Cancer Gene Therapy - Chimeric siRNA delivered to nasopharyngeal carcinoma cells

Cancer Gene Therapy - Colon cancer cell growth is stopped by cyclooxygenase-2 gene silencing

Cancer Gene Therapy - RNA interference in breast cancer cells enhances the effect of tamoxifen

Cancer Therapy - Anti-tumor immune responses enhanced by lung cancer cell fusion

Cancer Therapy - HER2-mediated tumorigenicity suppressed by modifying p27 Kip1

Cancer Therapy - Symporter-mediated iodide transport stimulated in breast cancer cells

Cancer Vaccine - Adenoviral vector expressing p53 gene may benefit patients with advanced cancer

Cancer Vaccine - Insulin-like growth factor binding protein-4 is antitumorigenic

Cancer Vaccine - Self-antigen has been optimized for epitope presentation in cancer immunity

Cardiology - Cardiac transmembrane protein structure and arrangement determined

Cell Physiology - Erlectin functions in N-glycan recognition

Cell Physiology - Ricin transport to the Golgi apparatus is regulated by Rab6A and Rab6A'

Collaborations - Windber Research Institute collaborates with Shanghai Center for Bioinformation Technology

Colon Cancer - Colon cancer chemoprevention and therapy finds new hope in acyclic retinoid

Cystic Fibrosis -  Pseudomonas aeruginosa-induced inflammatory response can be diminished

Cystic Fibrosis - CFTR cell surface expression is negatively regulated by calreticulin

DNA Research - Congenital defects diagnosed with high-density oligonucleotide arrays

DNA Research - Human I kappa B-zeta inhibits transactivation of p65 and its DNA binding

Dental Research - Porous chitosan/collagen provides scaffolding for periodontal tissue engineering

Developmental Biology - Connective tissue growth factor stimulates fibroblast collagen deposition

Developmental Biology - Induced retinal ganglion cell axon regeneration requires kinases

Developmental Biology - Oct4 homologues aid in maintaining vertebrate developmental multipotency

Diabetes Research - Gene therapy prevents the onset of hyperglycemia in diabetes-prone mice

Diabetes Therapy - Potential diabetes gene therapy using Epstein-Barr Virus vector has been developed

Drug Delivery - DNA-releasing microspheres aid DNA vaccine development

Drug Development - Corautus Genetics announces filing of response to U.S. Food and Drug Administration clinical hold

Drug Development - Data from Sangamo BioSciences' Diabetic Neuropathy Program published in Diabetes

Drug Development - Targeted Genetics presents encouraging interim data from trial of tgAAC94

Endometrial Carcinoma - Endometrial carcinomas affected by anti-tumor herbal medicines

Finance - Corautus Genetics receives NASDAQ deficiency notice related to minimum bid price

Finance - Dutton Associates announces investment opinion on Oragenics, initial rating at Speculative Buy

Finance - FoldRx Pharmaceuticals closes $43 million Series B financing

Gene Research - Gene therapy accelerates healing of damaged skeletal muscle

Genetics & Genomics - Atypical myeloproliferative disease involves plasminogen activator inhibitor

Genetics & Genomics - Cytomegalovirus protein hDaxx represses immediate-early gene expression

Genetics & Genomics - Steroid receptor coactivators' ablation affects hepatic metabolism

Genetics & Genomics - Unbiased location analysis suggests a widespread genomic role for E2F1

Glioma Vaccine - CXCR4 expression mediates glioma cell invasiveness

Imaging - Beta(2) adrenergic receptor conformation change imaged in living cells

Imaging - Time-lapse imaging of live human cells accomplishes RNAi screening

Immunoregulation - Siglec-H functions as an endocytic receptor on dendritic cell precursors

Infectious Diseases -  Bordetella pertussis infection is affected by toll-like receptor 4

Infectious Diseases - Bacterial endotoxin inhibits the enzymatic activity of human thrombin

Infectious Diseases - Hemagglutinin protease may function in Vibrio cholerae pathogenesis

Insulin-like Growth Factor Deficiency - European Commission grants Orphan Medicinal Product Designation to Increlex for primary IGFD

Kidney Disease - New immortalized glomerular endothelial cells reveal typical responses to VEGF

Mergers & Acquisitions - Covance expands its antibody products and services with acquisition of Signet Laboratories

Myocardial Infarction - Hepatocyte growth factor gene transfer induces artery growth and improves heart function