Cancer Vaccine

Adenoviral vector expressing p53 gene may benefit patients with advanced cancer

Published in Gene Therapy Weekly, June 29th, 2006

Intravenously administered Ad5CMV-p53, an adenoviral vector containing the wild-type p53 gene, may benefit patients with advanced cancer.

"The purpose of this study was to assess the feasibility of administering Ad5CMV-p53, an adenoviral vector containing the wild-type p53 gene to patients with advanced malignancies, characterize the pertinent pharmacokinetic parameters, identify evidence of viral uptake in both normal and tumor tissue, and seek evidence of antitumor activity. Patients were treated with escalating doses of Ad5CMV-p53 intravenously over 30 minutes on days 1, 2, and 3, every 28 days," scientists in the United States report.

"The...

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Source: Gene Therapy Weekly (2006-06-29)

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