Developmental Biology

Connective tissue growth factor stimulates fibroblast collagen deposition

Published in Gene Therapy Weekly, June 29th, 2006

According to research from the United States, connective tissue growth factor (CCV2, CTGF) stimulates collagen deposition by gingival fibroblasts via module 3 and alpha 6- and beta 1 integrins.

"CCN2/CTGF is a matricellular factor associated with fibrosis that plays an important role in the production and maintenance of fibrotic lesions. Increased collagen deposition and accumulation is a common feature of fibrotic tissues," wrote E.C.K. Heng and colleagues, Boston University.

"The mechanisms by which CCN2/CTGF contributes to fibrosis are not well understood. Previous studies suggest that CTGF exerts some of its biological effects at least in part by...

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Source: Gene Therapy Weekly (2006-06-29)

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