Published in Gene Therapy Weekly, June 29th, 2006
"CCN2/CTGF is a matricellular factor associated with fibrosis that plays an important role in the production and maintenance of fibrotic lesions. Increased collagen deposition and accumulation is a common feature of fibrotic tissues," wrote E.C.K. Heng and colleagues, Boston University.
"The mechanisms by which CCN2/CTGF contributes to fibrosis are not well understood. Previous studies suggest that CTGF exerts some of its biological effects at least in part by...
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