Allergy & Immunology
T cell receptor codon modification enhances functional expression
Published in Gene Therapy Weekly, June 29th, 2006
"Expression of native transgenic TCRs in recipient human T cells is often insufficient to achieve highly reactive T cell bulks," wrote K.B.J. Scholten and colleagues, Free University of Amsterdam.
They continued, "Here we show that codon modification of an HPV16E7-specific TCR, together with omission of mRNA instability motifs and (cryptic) splice sites, leads to a dramatic increase in the expression levels of the transgenic TCRs in human CD8+ T cells."
"The...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
Source: Gene Therapy Weekly (2006-06-29)
More Articles from Gene Therapy Weekly
- DNA Research
Aberrant ocular albinism gene splicing can be corrected - Immunotherapy
Immunotherapeutic potential of adenoviral-mediated gene transfer revealed - RNA Interference
Mammalian gene expression is artificially controlled by modulating RNA interference - RNA Interference
Short hairpin RNAs delivered into mouse embryonic stem cells - Respiratory Medicine
Airway inflammation is facilitated by local blockade of T-bet expression - Ameloblastoma
Ameloblastoma compared with dentigerous cyst via oligonucleotide microarrays - More from this issue of Gene Therapy Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
