Published in Gene Therapy Weekly, June 29th, 2006
"Expression of native transgenic TCRs in recipient human T cells is often insufficient to achieve highly reactive T cell bulks," wrote K.B.J. Scholten and colleagues, Free University of Amsterdam.
They continued, "Here we show that codon modification of an HPV16E7-specific TCR, together with omission of mRNA instability motifs and (cryptic) splice sites, leads to a dramatic increase in the expression levels of the transgenic TCRs in human CD8+ T cells."
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