Published in Gene Therapy Weekly, June 29th, 2006
"During sepsis, a two- to four-fold increase in circulating GH is seen with 40-50% reductions in plasma insulin-like growth factor (IGF)-I. The suppressors of cytokine signaling (SOCS), inhibitors of cytokine, and growth factor signaling via the janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway have been implicated in the development of hepatic GH resistance.
"In this study we examine the effects of sepsis on...
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