Virology

Hypoxic-response oncolytic parvovirus elements do not allow for increased vector production

Published in Gene Therapy Weekly, June 29th, 2006

According to recently published research from Belgium, hypoxic-response elements in the oncolytic parvovirus Minute virus of mice (MVM(p)) do not allow for increased vector production at low oxygen concentration.

"Vectors derived from the autonomous MVM(p) are promising tools for the gene therapy of cancer. The validation of their in vivo anti-tumour effect is, however, hampered by the difficulty to produce high-titre stocks," wrote C. Servais and colleagues, University Libre Bruxelles. "In an attempt to increase vector titres, host cells were subjected to low oxygen tension (hypoxia)."

"It has been shown that a number of viruses are produced at...

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Source: Gene Therapy Weekly (2006-06-29)

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