Gene Therapy Weekly
Susan Hasty, Publisher
Table of Contents . . . July 6th, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Gene Therapy Weekly | Other Publications
Antisense Technology - Suppressed c-fos expression impairs long-term memory in aversive taste learning
Developmental Biology - FAK and Pyk2 function differently in intestinal epithelial cell focal adhesions
Emphysema - Emphysema-like changes involve reverse tetracycline-transactivator gene expression
Gene Silencing - RNA interference-mediated gene silencing increased in embryonic carcinoma cells
Genetically Modified Cells - Genetically modified Schwann cells provide transplants in nerve regeneration
Apoptosis - Apoptosis is inhibited by a dominant negative form of p63
Apoptosis - Apoptosis signaling by epidermal growth factor receptor involves CARP-1
Apoptosis - Caspase-2-induced apoptosis requires bid cleavage
Apoptosis - Liver apoptosis lessened by inhibition of tumor necrosis factor receptor 1
Apoptosis - T-lymphoblastoid CEM cell apoptosis involves cleavage of 170-kDa P-glycoprotein
Biomedical Engineering - Ectopic bone formation is associated with a recombinant composite
Bone Formation - Osteoblastic cell heparanase expression stimulates bone formation and bone mass
Breast Cancer - Breast cancer invasion and metastasis prevented by targeting Pro interface
Breast Cancer - Breast tumor suppression influenced by genetic background of cancer cell lines
Breast Cancer Therapy - Vitamin D3 suppresses the androgen-stimulated growth of mammary carcinoma cells
Business Update - Children's Hospital of Philadelphia buys Illumina System to genotype children, conduct research
Business Update - Clinical Data division announces renewed DNA sequencing contract with Medical Research Council
Business Update - CyGene Laboratories Inc. launches predictive genomics product line based on new system
Business Update - Cyntellect receives $2.2 million milestone payment from Sigma-Aldrich Corporation
Business Update - Cytocell launches range of whole chromosome painting probes
Business Update - Digene announces CEO succession plan
Business Update - Kreatech, Qiagen sign supply pact for genome amplification technology kits, ULS technology
Cancer Gene Therapy - Adenovirus-mediated transfer of siRNA inhibits liver cancer cell growth
Cancer Gene Therapy - Chimeric oncolytic adenoviruses enhance gene transfer and oncolysis
Cancer Gene Therapy - HCC suppressed by adeno-associated virus-mediated apolipoprotein expression
Cancer Gene Therapy - Hepatoma radioiodine therapy achieved by targeted symporter gene transfer
Cancer Gene Therapy - Human B-cell lymphomas sensitized to cyclophosphamide
Cancer Gene Therapy - Introgen's advexin p53 therapy data show beneficial clinical activity in inherited cancer
Cancer Gene Therapy - Tumorigenic HBx and c-myc genes regulated using antisense recombinants
Cancer Research - Clinical data suggest Erbitux recruits immune system to help fight cancer
Cancer Therapy - Targeted molecular therapy, erlotinib HC1 combination inhibits tumor growth, studies show
Cancer Therapy - Transduction of cytotoxic T lymphocytes may be safe for cancer treatment
Cancer Vaccines - Celldex Therapeutics presents EGFRvIII vaccine data at ASCO meeting
Cardiology - Coxsackievirus myocarditis affects myocardial immunoproteasomes
Cardiovascular Research - Cardium reports meta-analysis findings of angiogenic gene therapy studies in heart disease
Cell Biology - Epidermal growth factor receptor activation mediates goblet cell metaplasia
Cell Biology - NK cell signaling dysregulation differentially regulates cytotoxicity
Cell Biology - Telomerase regulates myofibroblast differentiation
Cell Physiology - EagI potassium channel functions silenced by RNA interference
Cell Therapy - Photodynamic therapy plus intratumoral naive DC injection induces antitumor immunity
Chronic Myelogenous Leukemia - Cell Genesys reports long-term follow-up data from Phase 2 trial of GVAX immunotherapy in CML
Clinical Trials - Clinical data on Pharmion's oncology HDAC inhibitor MGCD0103 presented at ASCO
Clinical Trials - Clinical data on Pharmion's Vidaza (azacitidine for injectable suspension) presented at ASCO
Clinical Trials - Clinical trial confirms novel EGFR antibody targets tumors but not normal tissues
Collaborations - Dharmacon and amaxa collaborate to improve siRNA delivery into cells
Colon Cancer - Colon cancer invasion and liver metastasis suppressed by neutrophil gelatinase-associated lipocalin
Cystic Fibrosis - Small molecules rescue Delta F508-CFTR trafficking and gating
DNA Vaccine - Gene therapy method for articular cartilage lesions using naked DNA developed
Developmental Biology - Bone formation stimulated recombinant human bone morphogenetic protein-2 system
Developmental Biology - Cold-inducible RNA binding protein operates in embryonic Xenopus laevis
Developmental Biology - Developmental regulators suppressed in murine embryonic stem cells
Developmental Biology - Genes identified that are jointly required for somitic border specification
Developmental Biology - Lysosome maturation occurs in rat liver during perinatal development
Drug Delivery - Lilly, Alkermes complete patient enrollment for phase 3 safety study for inhaled insulin
Drug Development - Cell Genesys and Medarex announce interim results from Phase 1 combination therapy trial
Drug Resistance - Helicobacter pylori amoxicillin resistance involves multiple mutations
Finance - Sequenom closes $33 million equity financing with institutional investors
Gastroenterology - Cyclosporin A lowers serum and liver globotriaosyl ceramide levels
Genetics & Genomics - 11q loss and trisomy 12 linked to loss of imprinting of IGF2 in Wilms tumor
Genetics & Genomics - cDNA compared between dental pulp and mesenchymal stem cells
Genetics & Genomics - Clinical Data announces 2006 launch of genetic test for warfarin response
Genetics & Genomics - Pennsylvania children's hospital launches project to identify childhood diseases genes
Genetics & Genomics - Photosynthesis gene expression is regulated by an internal antisense RNA
HIV/AIDS Pathogenesis - HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells
Head & Neck Cancer - Apoptosis of squamous cell carcinoma of head and neck induced by Akt inhibitor KP372-1
Hepatitis B Virus - Anti-hepatitis B virus activity displayed by small RNAs
Hepatitis C Genetics - Epigenetic silencing influences interferon resistance of HCV replicon-harboring cells
Huntington Disease - Gene therapy preserves motor function, stops cellular changes in mice with Huntington Disease
Hypertension - Increased pulmonary hypertension increases oxidative stress
Imaging - Imaging of lung metastases model and gene therapy achieved
Immunotherapy - Immunotherapeutic outcome improved by H60/TNT-3 fusion protein
Immunotherapy - Therapeutic immunization attempted in chronic HBV carrier with a high viral load
Inflammatory Arthritis - Targeted Genetics reports study data on inflammatory arthritis product development platform
Influenza A Virus - RNA binding by influenza A viral protein inhibits RNase L pathway
Lung Cancer - Bcl-2 positivity predicts overall survival in advanced non-small cell lung cancers
Lung Cancer - Putative oncogenes identified in lung adenocarcinoma
Lung Cancer - Tumor phenotype and tumorigenicity of lung carcinoma cells reversed
Melanoma - Melanoma metastases express functional CXCR4
Multiple Myeloma - Multiple myeloma cell growth predominantly stimulated by bone-derived IGFs
Muscular Dystrophy - Mini-dystrophin/GFP fusion gene for studies of muscular dystrophy developed
Neuroscience - Amyloid precursor protein is involved in neural progenitor cell differentiation
Neuroscience - Focal cerebral ischemic damage can be salvaged by hemoglobin polymer transfusion
Neuroscience - Mutant huntingtin aggregates impair mitochondrial function in cortical neurons
Neuroscience - Prion protein amyloid fibrils are toxic to cultured cells and primary neurons
Neuroscience - Rac3-induced neuritogenesis requires binding to Neurabin I
Pediatric Acute Myeloid Leukemia - Seven genes monitor minimal residual disease in pediatric acute myeloid leukemia
Pediatric Hypertension - Hypoxia-induced neonatal pulmonary hypertension is influenced by Rac1 and RhoA
Personnel - Dr. David A. Evans, chief executive of WellGen, Inc., passes away after sudden illness
Personnel - Ronald B. Moss, MD, named vice president of clinical development for Vical Incorporated
Prion Proteins - Recombinant prions interact with compounds of therapeutical significance
Prostate Cancer - Cell Genesys recaps two presentations from 2006 ASCO Annual Meeting
Protein Deficiency Diseases - Inovio shows electroporation's potential to deliver gene-based treatments
Proteomics - Nucleolin interacts in a novel manner with Rad51
RNA Research - Self and nonself double-stranded RNAs distinguished in mammalian cells
RNA Research - shRNA expression in CD34+ progenitors avoids induction of siRNA interferon responses
Transplant Medicine - Changes in the transcriptome detected in allograft rejection
Type 2 Diabetes - ChemGenex discovery highlighted at international diabetes conference
Apoptosis - New findings from the People's Republic of China and Taiwan in the area of apoptosis described
Apoptosis - New research from Singapore, Spain and Japan in the area of apoptosis detailed
Breast Cancer - New research from Poland, Germany and the United States in the area of breast cancer detailed
Breast Cancer - Reports from Italy and the United States describe recent advances in breast cancer research
Cancer Research - New findings from the United States, Japan and Australia in the area of cancer described
Cancer Research - New findings in cancer described from the United States, People's Republic of China and South Korea
Cancer Research - Reports from the United States and People's Republic of China describe recent advances in cancer research
Cancer Treatment - Findings from Japan and Netherlands advance knowledge in cancer treatment research
Cancer Treatment - Reports from Italy, Japan and Canada advance knowledge in cancer treatment research
Cancer Treatment - Researchers from Canada, the United States and France detail new studies and findings in the area of cancer treatment
Cancer Treatment - Researchers from the People's Republic of China and United States describe findings in cancer treatment studies
Cell Biology - New findings in cell biology described from Singapore and the United States
Cell Biology - Researchers' work from the United States and South Korea adds to cell biology body of knowledge
DNA - Researchers from the United States, France and Sweden describe findings in DNA studies
Drug Delivery - Researchers' work from the United States and Wales adds to drug delivery body of knowledge
Genetics - Data from Israel and the United States advance knowledge in genetics research
Genetics - Recent findings from Japan, the United States and the United Kingdom illuminate research in genetics
Genetics - Reports from the United States and Canada advance knowledge in genetics research
Genetics - Researchers' findings from the United States, Singapore and South Korea advance genetics research
Hepatitis B Virus - Reports from the People's Republic of China, India and Japan describe recent advances in hepatitis B virus research
Hepatitis C Virus - New findings in hepatitis C virus described from Japan and the United Kingdom
Hepatocellular Carcinoma - Reports from Taiwan and Japan describe recent advances in hepatocellular carcinoma research
Hepatocellular Carcinoma - Researchers' data from Taiwan, Japan and the People's Republic of China advance hepatocellular carcinoma research
Imaging - Research from South Korea and United States in imaging provides new insights
Lymphoma - Researchers from Germany, the United States and Greece report recent findings in lymphoma
Macular Degeneration - Researchers from the United States, United Kingdom and People's Republic of China detail new studies and findings in the area of macular degeneration
Melanoma - Recent findings in melanoma described by researchers from the United Kingdom, Norway and Netherlands
Neurology - New research from Turkey, Germany and the South Korea in the area of neurology detailed
Neurology - Researchers from the United States report recent findings in neurology
Vectors - New findings in vectors described from the United States and Israel
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