Published in Gene Therapy Weekly, July 6th, 2006
"Oct4 and Nanog are transcription factors required to maintain the pluripotency and self-renewal of ES cells," wrote Y.H. Loh and colleagues, Genome Institute of Singapore.
"Using the chromatin immunoprecipitation paired-end ditags method, we mapped the binding sites of these factors in the mouse ES cell genome. We identified 1,083 and 3,006 high-confidence binding sites for Oct4 and Nanog, respectively....
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