Emphysema
Emphysema-like changes involve reverse tetracycline-transactivator gene expression
Published in Gene Therapy Weekly, July 6th, 2006
"The doxycycline-inducible, gene regulatory system allows tight control of transgene expression for the study of organ development and disease pathogenesis. Multiple recent reports have employed this model to investigate various lung diseases including emphysema," wrote T.H. Sisson and colleagues, University of Michigan.
They continued, "For our study, we used this transgenic system to test whether prolonged, lung-specific, overexpression of the Ser protease urokinase plasminogen activator (uPA) would...
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Source: Gene Therapy Weekly (2006-07-06)
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