Melanoma
Melanoma metastases express functional CXCR4
Published in Gene Therapy Weekly, July 6th, 2006
"The chemokine receptor CXCR4 was identified as an independent predictor of poor prognosis in primary melanoma. The aim of the study was to investigate the role of CXCR4 in human melanoma metastases," scientists in Italy report.
According to the authors, "Experimental CXCR4 expression was evaluated in melanoma metastases and in metastatic cell lines through immunohistochemistry, immunoblotting, immunofluorescence, and reverse transcription-PCR.
"The function of CXCR4 was tested in the presence of the ligand, CXCL12, through induction of extracellular signal-regulated kinase-1 and -2...
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Source: Gene Therapy Weekly (2006-07-06)
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