Gene Therapy Weekly
Susan Hasty, Publisher
Table of Contents . . . July 13th, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Gene Therapy Weekly | Other Publications
Gene Knockdown - Gene knockdown constructs generated with convergent H1 and U6 promoters
Hypertension - Genetic hypertension is ameliorated by specific kinase suppression
Orthopedics - Regulation of Runx2-stimulated osteogenesis can be induced
RNA Interference - Drosophila RNAi screen identifies specific kinases as nuclear factor regulators
RNA Research - Intracellular-diced dsRNA silences HCV RNA and overcomes genotypic variation
Apoptosis - Apoptosis detected using functionalized bimodal lipid-based contrast agents
Apoptosis - Apoptosis in myelodysplastic syndromes clarified
Apoptosis - Apoptosis protein auto-activation increases mitochondrial membrane permeability
Atherosclerosis - Atherosclerosis is affected by decreased heat shock protein 27 HSP27
Breast Cancer - Breast cancer cell survival requires acetyl-CoA carboxylase alpha
Breast Cancer - Breast cancer-induced bone destruction prevented by apoptosis-inducing ligand
Breast Cancer - Breast tumor progression-specific genes identified
Business & Finance - Enzo Biochem reports results for third fiscal quarter
Business Update - Ciphergen Biosystems, Inc. establishes scientific advisory board
Business Update - CytoGenix receives re-supply order for synDNA
Business Update - Once-monthly injectable medication for alcohol dependence now available in United States
Cancer Gene Therapy - Apoptosis is induced in human prostate cancer cells by antisense targeting
Cancer Gene Therapy - Endostatin therapy reveals a U-shaped curve for antitumor activity
Cancer Gene Therapy - Pancreatic tumor progression suppressed by promoter driven Bik mutant
Cancer Gene Therapy - Prostate cancer cell apoptosis induced by adenovirus-mediated ligand therapy
Cancer Gene Therapy - Selective adenovirus replication requires enhanced E1A expression in cancer cells
Cancer Gene Therapy - Squamous cell carcinoma adenoviral p53 gene therapy evaluated
Cancer Gene Therapy - Virotherapy-mediated hepatotoxicity studied in liver tissue
Cancer Therapy - Angiogenesis and tumor progression can be inhibited by genetic cotransfection
Cancer Therapy - Combination cancer therapy achieved by prodrug-activating enzymes and cytokines
Cancer Therapy - Intracranial tumor antigen immune response augmented with local immunotherapy
Cancer Therapy - Myc-mediated tumorigenesis explored using reversible kinetic analysis
Cancer Therapy - Renal cell carcinoma cytotoxicity enhanced by histone deacetylase inhibitors
Cell Biology - Caldesmon is an integral component of podosomes in smooth muscle cells
Cell Biology - Cortactin affects cell migration
Cell Therapy - Ex vivo expanded clinical grade natural killer cells prevent leukemia development
Chronic Myeloid Leukemia - ChemGenex launches multinational phase 2/3 study for CML patients with T315I mutation
Collaborations - Epigenomics AG announces research collaboration with Stanford University
Colorectal Cancer - Colorectal adenomas display allele-specific loss of heterozygosity
Complementary & Alternative Medicine - Yin-Chen-Hao decoction exerts protective effects on induced hepatitis
DNA Vaccine - Soluble sustained-release gene delivery system has been developed
Dental Research - Lentivirus-mediated RNAi probes gene function in mammalian tooth development
Developmental Biology - Bone morphogenetic protein diffusion and bone growth controlled by fibrin glue
Developmental Biology - Bone union enhanced in rat posterolateral fusion model
Developmental Biology - Ovarian primordial to primary follicle transition can be inhibited
Diabetes Research - Data on AIR Inhaled Insulin System presented at American Diabetes Association meeting
Drug Development - Cyclacel begins phase I pharmacologic study of oral sapacitabine in advanced leukemias
Embryonic Stem Cell Research - Embryonic stem cell pluripotency sufficiently maintained by Akt signaling activation
Finance - Clinical Data announces $17 million private placement
Finance - CombiMatrix announces $50 million equity financing commitment
Gene Research - Pediatric research team at Philadelphia hospital speeds search for chromosomal errors
Genetics & Genomics - Axl Tyr kinase receptor overexpressed in squamous cell skin cancers
Genetics & Genomics - HE4 expression in normal and malignant human tissues analyzed
Genetics & Genomics - MET overexpression turns human primary osteoblasts into osteosarcomas
Genetics & Genomics - Regulatory single nucleotide polymorphism causes a human genetic disease
Genetics & Genomics - Tandem repeat and transcription factor required in X chromosome inactivation
Glioma - SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion
HIV/AIDS Therapy - HIV-1 antiviral activity exhibited following delivery of double-stranded DNA
Hepatitis B Virus - Hepatitis B post-vaccination immune response is influenced by diet
Hepatitis B Virus - Hepatitis B virus replication facilitated by capsids
Herpes Simplex Virus - HSV Thy-kinase gene immuno 'stealth' derivative characterized
Human Papillomavirus - Papilloma lesion regression stimulated by recombinant vaccine
Imaging - Affibody presents clinical data on imaging of breast cancer metastases using anti-HER2 molecules
Legal Issues - Sigma-Aldrich, Oxford BioMedica file patent infringement lawsuit against Open Biosystems
Leukemia - Myeloid leukemia was linked to retroviral gene transfer to hematopoietic progenitor cells
Lipid Research - Preclinical study results show antisense drug inhibits cholesterol in mouse models
Lung Cancer - Non-small cell lung cancer transcriptional repressors are induced by prostaglandin
Melanoma - Melanomas display susceptibility toward replication-competent adenoviruses
Melanoma - TGen Foundation announces creation of Kristin Hornaday Fund for Melanoma Research
Melanoma Vaccine - Antigen-specific vaccination against melanomas evaluated
Myocarditis - TNFR-Fc fusion protein improves outlook in coxsackievirus induced myocarditis
Neuroscience - Burst firing of thalamic neurons is altered after spinal cord injury
Patents - Dermisonics receives Notice of Allowance from U.S. Patent & Trademark Office
Peripheral Nerve Sheath Tumors - Malignant peripheral nerve sheath tumors are vulnerable to oncolytic Herpes simplex virus mutants
Personnel - Chromos appoints new vice president, finance and chief financial officer
Personnel - Cougar Biotechnology appoints Michael Richman to board of directors
Prostate Cancer - Prostate cancer therapeutic potential of clusterin inhibition revealed
Proteomics - Functional indispensability of transmembrane domains revealed
Proteomics - Single-chain variable fragment antibody against asialoglycoprotein receptor has been characterized
Proteomics - Sulphation modulates siglec binding
Pulmonary Medicine - Chitosan-modified dry powder has been formulated for pulmonary gene delivery
Stem Cell Research - Connecticut to host international stem cell symposium
Type 2 Diabetes - Multiple antisense drugs are potential new treatments for metabolic disorders, studies show
Type 2 Diabetes - Study shows once-weekly exenatide LAR improved glucose control in type 2 diabetes patients
Vaccine Development - DNA plasmid vaccines display similar biodistribution
Vector Development - Molecular weight affects transfection efficiency of polyurethane gene vector
Vector Development - Mosaic vectors of adeno-associated virus 1 capsid proteins enhance targeting to vascular endothelial cells
Vector Development - Osmotic pressure affects retroviral vector stability
Vector Development - pH-responsive PEGylated polyplex micelle is developed as targetable nonviral vector
Vector Development - Recombinant SV40 vectors transduce microglia and protect against HIV
Wound Care - Diabetic wounds heal fast as topical gene therapy accelerates angiogenesis
Alzheimer Disease - Researchers from Italy and the United States provide details of new studies and findings in the area of Alzheimer disease
Cancer Research - Recent findings in cancer described by researchers from Canada, Germany and the United States
Cancer Research - Researchers from Denmark and the United States publish new studies and findings in the area of cancer
Cancer Research - Researchers' data from Japan, the People's Republic of China and the South Korea advance cancer research
Cancer Research - Researchers' work from Japan and the People's Republic of China adds to cancer body of knowledge
Cancer Research - Studies from the People's Republic of China, Japan and Ukraine add new findings to cancer body of knowledge
Cancer Treatment - Data from France, the United States and China advance knowledge in cancer treatment research
Cancer Treatment - Researchers' data from the People's Republic of China, United States and Denmark advance cancer treatment research
Diabetes - New findings from the United States and Sweden in the area of diabetes described
Diabetes - New findings in diabetes described from the United States, United Kingdom and Japan
Gene Therapy - Researchers from Germany and Japan provide details of new studies and findings in the area of gene therapy
Genetics - New findings from Japan in the area of genetics described
Genetics - New findings in genetics described from the United States, Italy and Germany
Genetics - Recent findings from Taiwan, the United States and Japan illuminate research in genetics
Genetics - Reports from the United States and United Kingdom add new data to genetics research
Genetics - Research from the United States, Spain and Iceland add new data to genetics body of knowledge
HIV/AIDS - Researchers' data from the United States advance HIV/AIDS research
HIV/AIDS - Researchers' findings from India and the United States advance HIV/AIDS research
Haemophilus - Researchers from Italy, the South Africa and the United States detail new studies and findings in the area of haemophilus
Hepatocellular Carcinoma - Studies from the United States, Germany and Spain describe new findings in hepatocellular carcinoma research
Herpes - Reports from the United States, Germany and Japan add new data to herpes research
Herpes - Studies from Japan, Netherlands and Italy advance knowledge in herpes research
Leukemia - Findings from the United Kingdom, Germany and United States in leukemia provide new insights
Lung Cancer - Recent studies from the United States and Japan add new data to lung cancer research
Neurology - Findings from Japan, the South Korea and the United States describe new data in neurology research
Neurology - Reports from the United States and Japan advance knowledge in neurology research
Neurology - Research from the People's Republic of China, Scotland and United States in neurology provides new insights
Neurology - Research from the United States, Austria and Canada in neurology provides new insights
Phenylketonuria - Reports from Switzerland, Japan and the United States advance knowledge in phenylketonuria research
Physiology - Data from the United States and France advance knowledge in physiology research
Physiology - Findings from the United States, People's Republic of China and South Korea advance knowledge in physiology research
Prostate Cancer - New findings from the United States in the area of prostate cancer detailed
Proteins - Reports from South Korea and United States add new data to proteins research
Transplants - Research from Japan and the United States in transplants provides new insights
Tumorigenesis - Recent findings from the United States and People's Republic of China illuminate research in tumorigenesis
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