Genetics
New findings in genetics described from the United States, Italy and Germany
Published in Gene Therapy Weekly, July 13th, 2006
Study 1: Recent research from the United States has reported on a gene profiling study of G3139- and Bcl-2-targeting siRNAs that identifies a unique G3139 molecular signature.
"G3139 is a phosphorothioate oligodeoxyribonucleotide that is targeted to the initiation codon region of the Bcl-2 mRNA, which downregulates Bcl-2 protein and mRNA expression via an antisense mechanism. In previous work, we have demonstrated that the phenotype observed in several prostate and melanoma cell lines after treatment with G3139 appears to be Bcl-2 independent.
"In...
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Source: Gene Therapy Weekly (2006-07-13)
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