Published in Gene Therapy Weekly, July 13th, 2006
"The interaction between CD40 ligand (CD40L) and CD40 on antigen presenting cells is essential for the initiation of antigen-specific T-cell responses, whereas CD40L stimulation of CD40+ tumor cells can induce cellular apoptosis. We investigated the anti-tumor effects induced by CD40L gene transfer into the mouse prostate adenocarcinoma cell line TRAMP-C2, both in vitro and in vivo," wrote H. Dzojic and colleagues, University of Uppsala.
"TRAMP-C2 cells were...
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