Published in Gene Therapy Weekly, July 13th, 2006
"A counting process senses the X chromosome/autosome ratio and ensures that XCI initiates in the early female (XX) embryo and in differentiating female ES cells but not in their male (XY) counterparts. Counting depends on the X inactivation center (Xic), which contains the Xist gene encoding a nuclear RNA, which coats the inactive X chromosome and induces gene silencing," wrote S. Vigneau and colleagues, Institute Pasteur.
"A 37-kb sequence lying 3' to the Xist gene is known to prevent initiation...
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