Pulmonary Medicine
Chitosan-modified dry powder has been formulated for pulmonary gene delivery
Published in Gene Therapy Weekly, July 13th, 2006
According to recent research from Wales, "Spray-drying is an effective process for preparing micron-dimensioned particles for pulmonary delivery. Previously, we have demonstrated enhanced dispersibility and fine particle fraction of spray-dried nonviral gene delivery formulations using amino acids or absorption enhancers as dispersibility-enhancing excipients. In this study, we investigate the use of the cationic polymer chitosan as a readily available and biocompatible dispersibility enhancer."
"Lactose-lipid:polycation:pDNA (LPD) powders were prepared by...
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Source: Gene Therapy Weekly (2006-07-13)
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