Published in Gene Therapy Weekly, July 20th, 2006
Study 1: According to a study from Switzerland, hippocampal up-regulation of NCAM expression and polysialylation plays a key role on spatial memory.
"Memory formation has been associated with structural and functional modifications of synapses. Cell adhesion molecules are prominent modulators of synaptic plasticity," wrote C. Venero and colleagues, Ecole Polytechnique Federale de Lausanne. "Here, we investigated the involvement of the cell adhesion molecules, NCAM, its polysialylated state (PSA-NCAM) and L1 in spatial learning-induced synaptic remodeling...
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