Cell Biology

Receptor activity is modulated by extracellular protons

Published in Gene Therapy Weekly, July 27th, 2006

According to research from the United States, human transient receptor potential vanilloid 1 (TRPV1) receptor activity is modulated by extracellular protons and host cell expression system.

"The TRPV1 receptor is a ligand-gated cation channel that can be activated by capsaicin, heat, protons and cytosolic lipids. We compared activation of recombinant human TRPV1 receptors stably expressed in human 293 cells, derived from kidney embryonic cells, and in human 1321N1 cells, derived from brain astrocytes," wrote B.R. Bianchi and colleagues, Abbott Laboratories.

"Cellular influx of calcium was measured in response to acid, endovanilloids...

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Source: Gene Therapy Weekly (2006-07-27)

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