Leukemogenesis
Persistent transactivation by Meis1 replaces Hox function in myeloid leukemogenesis
Published in Gene Therapy Weekly, August 3rd, 2006
According to a recently published article in the journal Molecular and Cellular Biology, Homeobox transcription factors MOO and Hoxa9 promote hematopoietic progenitor self-renewal and cooperate to cause acute myeloid leukemia (AML).
"While Hoxa9 alone blocks the differentiation of nonleukemogenic myeloid cell-committed progenitors, coexpression with Meis1 is required for the production of AML-initiating progenitors, which also transcribe a group of hematopoietic stem cell genes, including Cd34 and Flt3 (defined as Meis1-related leukemic signature...
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Source: Gene Therapy Weekly (2006-08-03)
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