Parkinson Disease
Far upstream element-binding protein identified as an authentic Parkin substrate
Published in Gene Therapy Weekly, August 3rd, 2006
"Aminoacyl-tRNA synthetase-interacting multifunctional protein type 2 was recently identified as an authentic substrate of the ubiquitin E3 ligase, parkin, a gene associated with autosomal recessive juvenile parkinsonism.
"Far upstream element-binding protein 1 is known to be degraded in an aminoacyl-tRNA synthetase interacting multifunctional protein type 2 dependent manner, which is crucial for lung cell maturation in early development," wrote H.S. Ko and colleagues, Johns Hopkins...
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Source: Gene Therapy Weekly (2006-08-03)
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