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Cardiology

Brain natriuretic peptide helps regulate cardiac ATPase expression

Published in Gene Therapy Weekly, August 10th, 2006

According to a study from Germany, brain natriuretic peptide participates in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase (SERCA2a) expression.

"In heart failure (HF), ventricular myocardium expresses brain natriuretic peptide (BNP). Despite the association of elevated serum levels with poor prognosis, BNP release is considered beneficial because of its antihypertrophic, vasodilating, and diuretic properties.

"However, there is evidence that BNP-mediated signaling may adversely influence cardiac remodeling, with further impairment of calcium homeostasis," wrote H. Kogler and colleagues, University of...

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