Developmental Biology

Retinal cell development affected by gene interference

Published in Gene Therapy Weekly, August 10th, 2006

In a recent report, researchers in Germany reported that the knock-down of glial cell line-derived neurotropic factor family receptor (GFR) alpha 4 expression by RNA interference affects the development of retinal cell types in three-dimensional histiotypic retinal spheres.

A. Rothermel and colleagues, University Leipzig, wrote that the study was done, "to determine the role of GFR alpha 4 during retino-genesis in a three-dimensional histiotypic in vitro model of the embryonic chicken retina."

"Retinal spheres were cultured from dissociated 6-day-old chicken retina under permanent rotation and trans-fected with GFR alpha 4 siRNA at culture day 2....

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Source: Gene Therapy Weekly (2006-08-10)

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