Vector Development
HIV-based lentiviral vectors transduce blood- and bone marrow-derived monocytes/macrophages
Published in Gene Therapy Weekly, August 10th, 2006
According to scientists in the United States, "Human immunodeficiency virus type 1-based defective lentiviral vectors (HIV-based vector) efficiently transduce a wide range of mammalian cell types, but little is known with respect to their utility for gene transfer applications involving primary mouse monocytes and macrophages. This may be important for preclinical development of a range of potential gene therapeutic modalities."
The present study describes the development of an optimized method for viral vector-mediated...
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Source: Gene Therapy Weekly (2006-08-10)
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