Published in Gene Therapy Weekly, August 17th, 2006
Study 1: Recent research from the United States has chronicled the pharmacological and electrophysiological characterization of store-operated currents and capacitative Ca2+ entry (CCE) in vascular smooth muscle cells.
"CCE in vascular smooth muscle cells contributes to vasoconstrictor and mitogenic effects of vasoactive hormones. In A7r5 rat aortic smooth muscle cells, measurements of cytosolic free Ca2+ concentration ([Ca2+](i)) have demonstrated that depletion of intracellular Ca2+ stores activates CCE.
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