Cancer Gene Therapy
Tumor growth suppressed by oncolytic adenovirus
Published in Gene Therapy Weekly, August 17th, 2006
"One of the challenges of oncolytic virotherapy is the inability to easily track or monitor virus activity during treatment. Here we describe the construction and functional characterization of Ad/hTC-GFP-E1, an oncolytic virus whose transgenes GFP and E1A are both under the control of a synthetic promoter (hTC)," wrote J.J. Davis and colleagues, M.D. Anderson Cancer Center.
"This promoter consists of sequences from the human telomerase reverse transcriptase...
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Source: Gene Therapy Weekly (2006-08-17)
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