HIV/AIDS Prevention
Tetraspanin domains inhibit macrophage infection by HIV
Published in Gene Therapy Weekly, August 17th, 2006
"HIV-1 infection of human macrophages can be inhibited by antibodies which bind to the tetraspanin protein CD63, but not by antibodies that bind to other members of the tetraspanin family. This inhibitory response was limited to CCR5 (R5)-tropic virus and was only observed using macrophages, but not T cells.
"Here, we show that recombinant soluble forms of the large extracellular domain (EC2) of human tetraspanins CD9, CD63, CD81, and CD151 produced...
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Source: Gene Therapy Weekly (2006-08-17)
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